Multilevel genome typing: genomics-guided scalable resolution typing of microbial pathogens

Vancomycin-resistant Enterococcus faecium high-resolution typing by core genome multilocus sequence typing.

TypOn: the microbial typing ontology

ABSTRACT Bacterial identification and characterization at subspecies level is commonly known as Microbial Typing. Currently, these methodologies are fundamental tools in Clinical Microbiology and bacterial population genetics studies to track outbreaks and to study the dissemination and evolution of virulence or pathogenicity factors and antimicrobial resistance. Due to advances in DNA sequenci...

High-Resolution HLA-A Typing in Normal Iranian Population

Background: Human leukocyte antigen (HLA) gene is a highly polymorphic region. HLA typing is required to match patients and donors for transplantation; therefore, development of HLA registries is necessary for finding HLA match donors. HLA system is highly informative, and numerous studies have been conducted on HLA allele distribution in different populations. Methods: In this study,...

Review on Molecular Typing Methods of Pathogens

This paper presents several common molecular typing methods, Pulsed-Field Gel Electrophoresis (PFGE), Restriction Fragment Length Polymorphisma (RFLP), Random Amplified Polymorphic DNA (RAPD), Automatic Ribotyping, rep-PCR, Multi-Locus Sequence Typing (MLST), in which the application and progress of molecular typing of pathgens for these methods are described. These methods played an important ...

Functional genomics of microbial pathogens.

1. Merhej V, Georgiades K, Raoult D. Postgenomic analysis of bacterial pathogens repertoire reveals genome reduction rather than virulence factors. Brief Funct Genomics 2013;12:291–304. 2. Chua KY, Stinear TP, Howden BP. Functional genomics of Staphylococcusaureus. BriefFunctGenomics 2013; 12:305–15. 3. Tymoshenko S, Oppenheim RD, Soldati-Favre D, et al. Functional genomics of Plasmodium falcip...